All patients with SLE with any degree and type of disease activity should be treated with hydroxychloroquine or chloroquine, unless these agents are contraindicated. Glucocorticoids or other immunosuppressive agents that may be used include mycophenolate, azathioprine, cyclophosphamide, or rituximab.

Epidemiology

Etiology

Pathophysiology

Clinical Features

Diagnostics

Treatment

Specific Clinical Manifestations

• Lupus Nephritis
• Neuropsychiatric Lupus
• Drug-induced Lupus (DILE)
• Cutaneous Lupus

Special Patient Groups

• SLE in Pregnancy & Antiphospholipid antibody syndrome

• Neonatal Lupus

Complications

Prognosis

Differential Diagnosis

<aside> 🤵🏻‍♂️ Smith is Specific in SLE! — Anti-smith antibodies are most specific in SLE

• Anti-dsDNA is also specific, most useful in treatment monitoring.
  • 2nd MC Ab in SLE, also associated with nephritis and vasculitis.
  • Anti-dsDNA is associated with disease activity </aside>

<aside> 👰🏻‍♀️ Anna is sensitive in SLE — ANA is most sensitive in SLE

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<aside> 😡 “He needs to lower his tone! I think he’s on drugs…” — Anti-histone antibodies are present in drug-induced lupus

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